Dermal Irritation - reversible skin damage that occurs as a result of applying a particular substance to the skin and appears shortly after application of the substance.

Ocular Irritation - reversible changes to the anterior surface of the eye following the application of a product or ingredient and appears shortly after application.

Dermal Sensitization - an immune response to a product or chemical resulting in allergic contact dermatitis.

Dermal Corrosion - Dermal corrosion is the production irreversible skin tissue damage usually as a result of corrosive tissue destruction (necrosis) following the application of a substance.

Ocular Corrosion - is the production of tissue damage in the eye, or serious physical decay of vision, following application of a test substance to the anterior surface of the eye, which is not fully reversible within 21 days of application.

Allergic Contact Dermatitis (ACD) - a skin reaction resulting from exposure to a substance, such as a hapten, that has the ability to illicit an immune response.

hapten - a foreign, low molecular weight substance that can penetrate the skin and when combined with specific skin proteins has the ability to produce an immune response, often resulting in allergic contact dermatitis.

in vitro - means in the glass, so it means the experiment is carried out outside of the organism, usually in a test tube or petri dish. In the case of this testing, it is carried out on a 3D skin or ocular models in tissue culture wells.

in vivo - means in life, so the experiment is carried out on the whole, living organism that the scientist is using as a subject.

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