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Staphylococcus saprophyticus


S. saprophyticus is a gram-positive, coccoid, coagulase-negative, non-hemolytic bacteria that is commonly a part of the human microflora in the perineum, rectum, urethra, cervix, and gastrointestinal tract.


Other than E. coli, S. saprophyticus is one of the most common causative agents in uncomplicated Urinary Tract Infections (UTIs). It can also be responsible for more serious complications such as urethritis, epididymitis, and prostatitis.


S. saprophyticus can be difficult to eliminate due to its ability to readily adhere to surfaces and subsequently form biofilms. This results in the fast-paced development of antibiotic resistance.


Alteration of the vaginal flora, such as spermicides and candidal infection, can increase the likelihood of infection by S. saprophyticus.


Argemi X, Hansmann Y, Prola K, Prévost G. Coagulase-Negative Staphylococci Pathogenomics. Int J Mol Sci. 2019 Mar 11;20(5)

Pinault L, Chabrière E, Raoult D, Fenollar F. Direct Identification of Pathogens in Urine by Use of a Specific Matrix-Assisted Laser Desorption Ionization-Time of Flight Spectrum Database. J Clin Microbiol. 2019 Apr;57(4)

Ehlers S, Merrill SA. Staphylococcus Saprophyticus. 2021 Jul 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 29493989.

Raz, Raul., Colodner, Raul., Kunin, Calvin M. 2005. Who are you-Staphylococcus saprophyticus? CID 2005:40 ppg. 896-898.


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