The Dermal Irritation Test is a test that is used to evaluate the potential of a product to cause skin irritation when used by the consumer. Some cosmetic products can cause skin irritation by passing through the outer layer of the skin (called the stratum corneum) and enter the layers beneath causing toxic effects to those cells. This, in turn, causes an immediate immune response that is typically characterized by redness, and itching or pain in the area of contact with the product.
The Dermal Irritation test utilizes 3-dimensional skin models to test for skin irritation. This in vitro model is a great replacement for the in vivo testing performed on animals since several in vivo tests for cosmetic ingredients have now been banned for use in many areas. The Dermal irritation model can determine if a chemical or ingredient in your product is able to penetrate the outer layer of the skin and cause a cytotoxic effect on the cells beneath. If the effect is weak or cannot be detected, a quantifiable amount of inflammatory mediators is released by the skin model and may be used to increase the sensitivity of the test. The model can be used to test liquids and solids. Extensive validation has been done on these in vitro models to verify high concordance with in vivo findings.
The FDA requires the makers and formulators of cosmetic and personal care products to substantiate the safety of their products prior to marketing them. This skin irritation model is a fast and easy way to meet your cosmetic safety testing needs.