In 2006, interested in evaluating virucidal activity, Advanced Vapor Technologies contracted studies at Microbiotest against feline calicivirus (a norovirus surrogate), avian influenza virus, and canine parvovirus at contact times ranging from 7 to 10 seconds. These studies also demonstrated excellent virucidal efficacy.
At the height of the company’s interest in their unique approach to surface disinfection in 2007, Advanced Vapor Technologies was introduced to a startup laboratory in Northern California called Microchem Laboratory.
The timing couldn’t have been better. Rick informed this new lab of the encouraging scientific findings to date. Dr. Benjamin Tanner, principal of Microchem Laboratory, designed and proposed a series of pioneering studies to expand the body of research.
Data from Nelson Labs and Microbiotest indicated that the Advanced Vapor Technologies MondoVap system disinfected within a very brief period. To determine time-to-sanitization and time-to-disinfection, Microchem Laboratory conducted a series of studies at ultra-brief contact times, ranging from 1/2 second to 5 seconds.
To facilitate accurate research at such brief contact periods, Microchem Laboratory partnered with a local metalworking company to machine custom test-surface holders that were stable when treated with the device, but easily manipulated using laboratory instruments.
Testing and Collaboration
In keeping with Microchem Laboratory culture of robust study design, initial microorganism populations were great, at approximately 10^6 cfu/test surface. In addition, test surfaces chosen for the study were “worst case” in that they had considerable surface texture.
The studies showed that in general the device sanitized (99.9% reduction) within just 2 seconds and disinfected surfaces within 3-5 seconds. This was a true “first” with regard to surface disinfection: Contact times as brief as 2-3 seconds to achieve surface sanitization and disinfection. These contact times have yet to be rivaled by chemical disinfectants. Accordingly, Dr. Tanner worked with Advanced Vapor Technologies to write up and eventually publish the research in the peer-reviewed American Journal of Infection Control (a list of laboratory-related publications, including the AJIC article, can be found here).
A series of other studies were conducted at Microchem Laboratory, all of which were designed to be scientifically robust, informative, and valuable to the client. For example, studies were designed to evaluate practical questions such as whether five 1-second treatments were as effective as one 5-second treatment. Tests were also conducted to evaluate aerosolization of surface microorganisms resulting from use of the device and the potential for cross-contamination of surfaces. All studies produced favorable and marketable results, testament to the robustness of the process with regard to surface disinfection.
In 2007, Microchem Laboratory moved to the Austin, Texas area but that did not stop the line of research into steam disinfection. An “in-hospital” effectiveness study was designed with Dr. Charles Gerba (University of Arizona) and eventually published in AJIC (laboratory publication link). Later, effectiveness of the device against the tough endospores of Clostridium difficile was measured.
Microchem Laboratory and Advanced Vapor Technologies worked seamlessly together to evaluate the device. In the process, the science of steam disinfection of surfaces was furthered considerably. Since then, Advanced Vapor Technologies has continued to test and learn about the device, most recently working with the Toxic Use Reduction Institute (TURI), Lowell University, Massachusetts, to evaluate efficacy of the device on textiles such as hospital curtains.
As a result of the large body of research conducted by Microchem Laboratory, other labs, and Universities, Advanced Vapor Technologies devices now enjoy wide usage in a number of prominent hospitals, where environmental services personnel reliably disinfect surface after surface, without many of the drawbacks associated with ordinary chemical disinfectants.
“We are very pleased with Microchem Laboratory. Innovative systems such as ours require an equally innovative service provider. Microchem has a supportive staff, willing to go the extra mile. Reliability of their results are beyond reproach and reproducible within the GLP framework. Microchem Laboratory has been a pleasure to work with, regardless of the size or scope of the project.” – Rick Hoverson, Advanced Vapor Technologies