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USP <51> – Preservative Challenge Test

Introduction The USP Chapter 51 Preservative Challenge Test is the most common method used to gauge preservative effectiveness.  Much like a Preservative Challenge Screen, it is used to evaluate the effect of preservatives in cosmetics, personal care products, and drug products. Preservatives are antimicrobial ingredients that are added to aqueous...

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USP <61> – Microbial Enumeration Test

The USP <61> - Microbial Enumerations Test is a product safety test found in Chapter 61 of the United States Pharmacopeia. It is suggested for use by the FDA for pharmaceuticals as well as cosmetics and personal care products to ensure that a product's preparation complies with pre-set specifications...

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USP 51 Antimicrobial Effectiveness Test

USP <51> is used to test preservative effectiveness. The number "<51>" refers to General Chapter 51 of the United States Pharmacopeia (USP) National Formulary. Chapter 51 describes in detail the USP method for preservative efficacy testing, sometimes called "preservative challenge testing." If you would like to learn more about the...

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Zone of Inhibition Test for Antimicrobial Activity

A Zone of Inhibition Test, also called a Kirby-Bauer Test, is a qualitative method used clinically to measure antibiotic resistance and industrially to test the ability of solids and textiles to inhibit microbial growth. Researchers who develop antimicrobial textiles, surfaces, and liquids use this test as a quick and...

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Wound Dressing Microbial Ingress Testing

Wound Dressing Microbial Ingress Test Microbial Ingress Testing is the evaluation of the ability of a medical device, such as a wound dressing, to resist or inhibit the transfer of infectious microorganisms under repeated simulated use conditions. Many wound dressings have features that could potentially allow microorganisms a point of...

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Tuberculocidal Activity of Disinfectants (AOAC 965.12)

The AOAC Tuberculocidal Activity of Disinfectants method is specified by US EPA as a method which can be used to substantiate tuberculocidal efficacy claims for disinfectants. It is a modified version of the AOAC Use-Dilution test method and particularly appropriate for dilutable disinfectants. Summary of the AOAC Tuberculocidal Activity of...

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UV Room Disinfection Devices

UV light is a reliable, well-studied antimicrobial technology. It works primarily by destroying the DNA inside bacteria, viruses and fungi. The high-energy portion of the UV spectrum called UV-C is most effective. UV-C light has been used for decades to disinfect industrial surfaces and sanitize drinking water. It is...

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USP <61> Microbial Examination of Nonsterile Products

The US Pharmacopeial Convention (USP) has developed and maintains a compendium of several test methods, which are utilized by companies that produce drugs and cosmetics to ensure quality and product integrity. Individual chapters of the compendium - each detailing a different test method - are identified by the chapter...

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Towelette Preservative Challenge Test For Cosmetics

Many cosmetics and personal care products are now available in the form of pre-saturated towelettes or wipes. Like the majority of personal care products having an aqueous base, pre-saturated towelettes are susceptible to microbial contamination and require a preservation system to protect them from degradation. Cosmetics and personal care...

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Simulated Use Test for High-Level Disinfectants

Prior to initiation of the experiment, the active ingredient in the test substance is measured, the pH is taken and the concentration of the test substance is validated using titration analysis. Then, the test substance is diluted to the minimum recommended concentration (MRC) and confirmed again by titration analysis...

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Rinsability Test

In the usage of high-level disinfectants, the possibility of contact with these substances is something that needs to be ensured does not occur if the active ingredient could be harmful. To ensure that the level of active ingredient in/on the surface in question is at a level that would...

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Virucidal Towelettes Effectiveness Test

Virucidal Efficacy Guidelines The U.S. EPA recommends the use of internationally-recognized standard test methods as the basis for pre-saturated towelette virucidal efficacy evaluations: AOAC Germicidal Spray Products as Disinfectants Test, Modified for Wipes Brief Summary of the Test The U.S. EPA recommends the use of internationally-recognized standard test methods as the basis for...

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